Tuesday, February 22, 2011

No I am NOT killing myself

kw: articles, medicine, safety, sweeteners

For the record, I drink about a liter of Diet Pepsi daily. It is sweetened with aspartame. My doctor and others get on my case about that. Here is some 21-year-old news from Archives of Internal Medicine:

Safety of Long-term Large Doses of Aspartame

Arthur S. Leon, MD; Donald B. Hunninghake, MD; Catherine Bell, MBA; David K. Rassin, PhD; Thomas R. Tephly, MD, PhD

Arch Intern Med. 1989;149(10):2318-2324.


• Safety of long-term administration of 75 mg/kg of aspartame per day was evaluated with the use of a randomized, double-blind, placebo-controlled, parallel-group design in 108 male and female volunteers aged 18 to 62 years. Subjects received either aspartame or placebo in capsule form three times daily for 24 weeks. No persistent changes over time were noted in either group in vital signs; body weight; results of standard laboratory tests; fasting blood levels of aspartame's constituent amino acids (aspartic acid and phenylalanine), other amino acids, and methanol; or blood formate levels and 24-hour urinary excretion of formate. There also were no statistically significant differences between groups in the number of subjects experiencing symptoms or in the number of symptoms per subject. These results further document the safety of the long-term consumption of aspartame at doses equivalent to the amount of aspartame in approximately 10 L of beverage per day.

This won't end the matter. People are going to believe what they want to believe, even my doctor, who claims to believe in "evidence based medicine", but only does so when it fits his prejudices. The article is sufficient for me.

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